Decoding the signaling and repertoire threshold

required for immune tolerance



Welcome to the ASHOURI Lab

We study antigen-receptor signaling pathways that disrupt immune tolerance and result in autoimmune disease.  We utilize mouse models, humans samples, along with molecular, cell-based, and multi-omic technologies including paired single-cell RNA and TCR-sequencing. Our goal is to identify the TCR specificities, gene expression profile, and signaling networks of cells involved in antigen recognition in rheumatoid arthritis and other related autoimmune diseases.

Ashouri Lab website is under development. Please contact us if you have any questions or would like to join the lab!