Publications

ZAP70, too little, too much can lead to autoimmunity

Impaired TCR signaling in SKG mice and an altered T cell repertoire along with chronic endogenous antigen encounter confer increased arthritogenicity of selfreactive T cell clones in SKG mice.

Ashouri et al. Immunological Reviews. 2021

Hepatic Ly6C^Lo Non-Classical Monocytes Have Increased Nr4a1 (Nur77) in Murine Biliary Atresia
Sarah Mohamedaly, Claire S Levy, Cathrine Korsholm, Anas Alkhani, Katherine Rosenberg, Judith F Ashouri, Amar Nijagal
Journal of Clinical Medicine, 2022

Naïve arthritogenic SKG T cells have a defect in anergy and a repertoire pruned by superantigen.
Ashouri JF*, McCarthy E, Yu S, Perlmutter N, Lin C, DeRisi J, Ye J*, Weiss A*. *co-corresponding authors
BioRxiv, 2022

ZAP70, too little, too much can lead to autoimmunity.
Ashouri JF, Lo WL, Nguyen TTT, Shen L, Weiss A
Immunologic Reviews, 2021

The Therapeutic Landscape of Rheumatoid Arthritis: Current State and Future Directions.
Shams S, Martinez JM, Dawson JRD, Flores J, Gabriel M, Garcia G, Guevara A, Murray K, Pacifici N, Vargas MV, Voelker T, Hell JW, Ashouri JF.
Frontiers in Pharmacology, 2021

Cross-Tissue Transcriptomic Analysis Leveraging Machine Learning Approaches Identifies New Biomarkers for Rheumatoid Arthritis.
Rychkov D, Neely J, Oskotsky T, Yu S, Perlmutter N, Nititham J, Carvidi A, Krueger M, Gross A, Criswell LA, Ashouri JF, Sirota M
Frontiers in Immunology, 2021

Therapeutic Implications of Diet in Inflammatory Bowel Disease and Related Immune-Mediated Inflammatory Diseases.
Jiang Y, Jarr K, Layton C, Gardner CD, Ashouri JF, Abreu MT, Sinha SR
Nutrients, 2021

Efficacy of Dietary Supplements in Inflammatory Bowel Disease and Related Autoimmune Diseases.
Jadhav P, Jiang Y, Jarr K, Layton C, Ashouri JF*, Sinha SR*. *co-corresponding authors
Nutrients, 2020

Developing Human Skin Contains Lymphocytes Demonstrating a Memory Signature.
Dhariwala MO, Karthikeyan D, Vasquez KS, Farhat S, Weckel A, Taravati K, Leitner EG, Clancy S, Pauli M, Piper ML, Cohen JN, Ashouri JF, Lowe MM, Rosenblum MD, Scharschmidt TC
Cell Reports, Medicine, 2020

Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis.
JF Ashouri, L-Y Hsu, S Yu, Y Chen, DA Cheng, E Hansen, L Lattanza, J Zikherman, A Weiss
Proc Natl Acad Sci U S A, 2019

Endogenous Nur77 is a specific indicator of antigen receptor signaling in human T and B cells.
Ashouri JF, Weiss A
Journal of Immunolology, 2017

A Sharp TCR Signaling Threshold for T cell Proliferation.
B Au-Yeung, J Zikherman, J Mueller, J Ashouri, D Cheng, Y Chen, K Shokat, and A Weiss
Proc Natl Acad Sci U S A, 2014

A Young woman with systemic lupus erythematosus and extensive mesenteric vasculitis involving small and medium vessels.
Ashouri JF, Davis JL, Farkas A, Durack JC, Ramachandran R, Dall'Era M
Arthitis Care & Research, 2012

Rheumatic Manifestations of Cancer.
Ashouri JF, Daikh DI
Rheum Dis Clin N Am, 2011

Transcriptional regulation of EGR-1 by the interleukin-1-JNK-MKK7-c-Jun pathway.
Hoffmann E*, Ashouri J*, Wolter S*, Doerrie A, Dittrich-Breiholz O, Schneider H, Wagner E, Troppmair J, Mackman N, Kracht M. *contributed equally
Journal of Biological Chemistry, 2008

Androgens are protective in experimental autoimmune encephalomyelitis: implications for multiple sclerosis.
Palaszynski KM, Loo KK, Ashouri JF, Liu HB, Voskuhl RR.
Journal of Neuroimmunolology, 2004

Estrogen receptor alpha mediates estrogen's immune protection in autoimmune disease.
Liu HB, Loo KK, Palaszynski K, Ashouri J, Lubahn DB, Voskuhl RR.
Journal of Immunology, 2003