Judith Ashouri Sinha, MD

Principal Investigator, Assistant Professor

Department of Medicine

Division of Rheumatology & Immunology

+1 415 476-7160

Rheumatoid arthritis (RA) afflicts millions globally, causing significant joint deformity, pain, and functional disability. RA is without cure and its cause is unknown, but CD4 T cells—immune cells widely accepted to play a key role in RA pathogenesis—from patients with RA become activated by proteins through their T cell receptor (called “antigen-specific T cells”) and cause arthritis. Dr. Ashouri’s research uses a unique tool to identify and characterize these antigen-activated T cells in both a mouse model of RA and human RA. Elucidating the contribution of these pathogenic CD4 T cells to arthritis development in RA holds promise for the discovery of improved therapeutic targets.

Publications:

Endogenous antigens shape the transcriptome and TCR repertoire in an autoimmune arthritis model.

The Journal of clinical investigation

McCarthy EE, Yu S, Perlmutter N, Nakao Y, Naito R, Lin C, Riekher V, DeRisi J, Ye CJ, Weiss A, Ashouri JF

Repeated immunization with ATRA-containing liposomal adjuvant transdifferentiates Th17 cells to a Tr1-like phenotype.

Journal of autoimmunity

Wørzner K, Zimmermann J, Buhl R, Desoi A, Christensen D, Dietrich J, Nguyen NDNT, Lindenstrøm T, Woodworth JS, Alhakeem RS, Yu S, Ødum N, Mortensen R, Ashouri JF, Pedersen GK

Hepatic Ly6CLo Non-Classical Monocytes Have Increased Nr4a1 (Nur77) in Murine Biliary Atresia.

Journal of clinical medicine

Mohamedaly S, Levy CS, Korsholm C, Alkhani A, Rosenberg K, Ashouri JF, Nijagal A

ZAP70, too little, too much can lead to autoimmunity.

Immunological reviews

Ashouri JF, Lo WL, Nguyen TTT, Shen L, Weiss A

Cross-Tissue Transcriptomic Analysis Leveraging Machine Learning Approaches Identifies New Biomarkers for Rheumatoid Arthritis.

Frontiers in immunology

Rychkov D, Neely J, Oskotsky T, Yu S, Perlmutter N, Nititham J, Carvidi A, Krueger M, Gross A, Criswell LA, Ashouri JF, Sirota M

The "Prediction of Alcohol Withdrawal Severity Scale" (PAWSS): systematic literature review and pilot study of a new scale for the prediction of complicated alcohol withdrawal syndrome.

Alcohol (Fayetteville, N.Y.)

Maldonado JR, Sher Y, Ashouri JF, Hills-Evans K, Swendsen H, Lolak S, Miller AC

Ashouri Lab

Judith Ashouri Sinha, MD

Endogenous antigens shape the transcriptome and TCR repertoire in an autoimmune arthritis model.

Repeated immunization with ATRA-containing liposomal adjuvant transdifferentiates Th17 cells to a Tr1-like phenotype.

Hepatic Ly6CLo Non-Classical Monocytes Have Increased Nr4a1 (Nur77) in Murine Biliary Atresia.

ZAP70, too little, too much can lead to autoimmunity.

Cross-Tissue Transcriptomic Analysis Leveraging Machine Learning Approaches Identifies New Biomarkers for Rheumatoid Arthritis.

The Therapeutic Landscape of Rheumatoid Arthritis: Current State and Future Directions.

Therapeutic Implications of Diet in Inflammatory Bowel Disease and Related Immune-Mediated Inflammatory Diseases.

Developing Human Skin Contains Lymphocytes Demonstrating a Memory Signature.

Efficacy of Dietary Supplements in Inflammatory Bowel Disease and Related Autoimmune Diseases.

Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis.

Endogenous Nur77 Is a Specific Indicator of Antigen Receptor Signaling in Human T and B Cells.

A sharp T-cell antigen receptor signaling threshold for T-cell proliferation.

The "Prediction of Alcohol Withdrawal Severity Scale" (PAWSS): systematic literature review and pilot study of a new scale for the prediction of complicated alcohol withdrawal syndrome.

A young woman with systemic lupus erythematosus and extensive mesenteric vasculitis involving small and medium vessels.

Rheumatic manifestations of cancer.

Transcriptional regulation of EGR-1 by the interleukin-1-JNK-MKK7-c-Jun pathway.

Androgens are protective in experimental autoimmune encephalomyelitis: implications for multiple sclerosis.

Estrogen receptor alpha mediates estrogen's immune protection in autoimmune disease.

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Judith Ashouri Sinha, MD