
Principal Investigator, Assistant Professor
Department of Medicine
Division of Rheumatology & Immunology
+1 415 476-7160
Rheumatoid arthritis (RA) afflicts millions globally, causing significant joint deformity, pain, and functional disability. RA is without cure and its cause is unknown, but CD4 T cells—immune cells widely accepted to play a key role in RA pathogenesis—from patients with RA become activated by proteins through their T cell receptor (called “antigen-specific T cells”) and cause arthritis. Dr. Ashouri’s research uses a unique tool to identify and characterize these antigen-activated T cells in both a mouse model of RA and human RA. Elucidating the contribution of these pathogenic CD4 T cells to arthritis development in RA holds promise for the discovery of improved therapeutic targets.
Publications
Endogenous antigens shape the transcriptome and TCR repertoire in an autoimmune arthritis model.
The Journal of clinical investigation
Repeated immunization with ATRA-containing liposomal adjuvant transdifferentiates Th17 cells to a Tr1-like phenotype.
Journal of autoimmunity
Hepatic Ly6CLo Non-Classical Monocytes Have Increased Nr4a1 (Nur77) in Murine Biliary Atresia.
Journal of clinical medicine
ZAP70, too little, too much can lead to autoimmunity.
Immunological reviews
Cross-Tissue Transcriptomic Analysis Leveraging Machine Learning Approaches Identifies New Biomarkers for Rheumatoid Arthritis.
Frontiers in immunology
The Therapeutic Landscape of Rheumatoid Arthritis: Current State and Future Directions.
Frontiers in pharmacology
Developing Human Skin Contains Lymphocytes Demonstrating a Memory Signature.
Cell reports. Medicine
Efficacy of Dietary Supplements in Inflammatory Bowel Disease and Related Autoimmune Diseases.
Nutrients
Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis.
Proceedings of the National Academy of Sciences of the United States of America
Endogenous Nur77 Is a Specific Indicator of Antigen Receptor Signaling in Human T and B Cells.
Journal of immunology (Baltimore, Md. : 1950)
A sharp T-cell antigen receptor signaling threshold for T-cell proliferation.
Proceedings of the National Academy of Sciences of the United States of America
The "Prediction of Alcohol Withdrawal Severity Scale" (PAWSS): systematic literature review and pilot study of a new scale for the prediction of complicated alcohol withdrawal syndrome.
Alcohol (Fayetteville, N.Y.)
A young woman with systemic lupus erythematosus and extensive mesenteric vasculitis involving small and medium vessels.
Arthritis care & research
Rheumatic manifestations of cancer.
Rheumatic diseases clinics of North America
Transcriptional regulation of EGR-1 by the interleukin-1-JNK-MKK7-c-Jun pathway.
The Journal of biological chemistry
Androgens are protective in experimental autoimmune encephalomyelitis: implications for multiple sclerosis.
Journal of neuroimmunology
Estrogen receptor alpha mediates estrogen's immune protection in autoimmune disease.
Journal of immunology (Baltimore, Md. : 1950)